Andrea Bonetti • Roberto Leone Franco M. Muggia • Stephen B. Howell Editors 2009 Molecular Mechanisms and Clinical Applications Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a […]

E. Rehbinder . M. Engelhard . K. Hagen . R. B. Jørgensen . R. Pardo-Avellaneda . A. Schnieke . F. Thiele 2009 Promises and risks of biopharmaceuticals derived from genetically modified plants and animals The Europäische Akademie deals with the scientific study of the consequences of scientific and technological advances for individuals and society, as well as […]

Andreas Bernkop-Schnürch Editor 2009 Barriers, Strategies and Future Trends Due to a rapid development in biotechnology more and more macromolecular drugs such as therapeutic peptides, oligosaccharides and nucleic acids are entering the pharmaceutical arena representing unprecedented challenges from the drug delivery point of view. One of the likely greatest challenges is their oral administration presenting a series of attractive […]

Reginald L. Dean III · Edward J. Bilsky S. Stevens Negus Editors 2009 From Bench to Clinic The evolution in our understanding of opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis, and movement disorders.

Lyudmila Larina ● Valentin Lopyrev 2009 The present monograph is devoted to the chemistry of nitroazoles, one of the most interesting series of heteroaromatic compounds. The azoles hold a special position in the chemistry of heterocycles. Their unique properties and specific biological activity attract much attention of research chemists all over the world. During the last years the interest […]

Melgardt M. de Villiers Pornanong Aramwit Glen S. Kwon 2009 Nanotechnology, a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices, or systems on the nanometer scale and is currently undergoing explosive development on many fronts. It is expected to spark innovation and play a critical role in various biomedical applications, especially in drug delivery, as is shown […]

Edited by Andreas Luch 2009 Toxicology is the science of poisons and the study of adverse effects of chemical agents upon living organisms. The root of the word “toxic” is taken from the Latin word toxicus (meaning poisonous), which is itself derived from the ancient Greek word toxikon, a term used to describe poisons into which arrows were dipped […]

Amittha Wickrema • Barbara Kee Editors 2009 Hematopoiesis is among the most thoroughly studied tissue systems investigated in humans and other organisms. This is true for many reasons, especially because of the accessibility of samples from finger prick, venipunctures, or leukophoresis to bone marrow aspiration. The availability of mouse models and genetic mutations, some of which mimic human diseases, […]

Zhiguo Wang 2009 MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22- nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species. Accumulating evidence suggests that miRNAs constitute a novel, universal mechanism for fine regulation of gene expression in all organisms, “fine tuning” the cellular phenotype during delicate […]

Nobuhiro Fusetani • William Kem Editors 2009 There has been a steady increase in the number of known marine toxins in the past few decades. The remarkable molecular diversity of these and other marine natural products probably exceeds the diversity of organisms that live in the sea. Earlier pioneering books on marine toxins such as those by Halstead […]