Editor Anne Le 2021 Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic fexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism […]

Anton Bespalov • Martin C. Michel • Thomas Steckler Editors 2020 Pharmacologists and other experimental life scientists study samples to infer conclusions about how a molecule, cell, organ, and/or organism work in health and disease and how this can be altered by drugs. The concept of inference implies that whatever is reported based on the […]

Kota Miura Nataša Sladoje Editors 2020 The often-posed question among life science researchers, “Which software tool is the best for bioimage analysis,” indicates misunderstanding which calls for explanations. It appears that this question cannot be answered easily, maybe even not at all. Biological research problems are not general, and each of them questions specific events […]

Francisco M. Couto 2019 During the last decades, I witnessed the growing importance of computer science skills for career advancement in Health and Life Sciences. However, not everyone has the skill, inclination, or time to learn computer programming. The learning process is usually time consuming and requires constant practice, since software frameworks and programming languages […]

Gerd Pluschke • Katharina Röltgen Editors 2019 Mycobacterium Ulcerans Disease Within the 20 years after WHO has launched the Global Buruli Ulcer Initiative in 1998, considerable progress has been made toward the understanding and the control of this neglected, once mysterious, tropical skin disease. Major practical achievements were the evaluation and successful introduction of an antibiotic […]

Bruce Spiegelman Editor 2017 We gathered in Paris to present new work on exercise and the molecular understanding of its actions and benefits. Exercise has been understood for centuries to provide benefits to the human body. Diet and exercise have long been prescribed as the first lines of therapy for metabolic diseases such as obesity and […]

Mitchell Fry 2010 To the uninitiated, biochemistry is a complex and intricate subject, but importantly it is a subject that underpins the biosciences, including medicine. As a university lecturer, and by training a biochemist, I have taught my subject to both ‘my own’ students, and to those on allied degree schemes and pre-clinical medicine. Of course, the lines […]

Edited by Stefan Pöhlmann Graham Simmons 2013 For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a […]

Yuichi Sugiyama • Bente Steffansen Editors 2013 Discovery, Optimization, Clinical Study and Regulation This volume of AAPS Advances in Pharmaceutical Sciences Series presents a review of the principles and progress concerning membrane transporters and how evolved understanding of membrane transporters has influenced drug development and regulatory assessment. The objective of the book is to present current knowledge in […]

Gary Hime • Helen Abud Editors 2013