Andrea Bonetti • Roberto Leone
Franco M. Muggia • Stephen B. Howell
Editors

2009

Molecular Mechanisms
and Clinical Applications

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens.