Ribosomes are the organelles that synthesize proteins according to the genetically encoded information. Whereas prokaryotic ribosomes were even reconstituted in vitro, eukaryotic ribosomes are more complex. In yeast—as a eukaryotic model organism—about 5–10% of the genomic capacity is needed for the biogenesis of a ribosome. Worldwide a remarkable number of laboratories is investigating all aspects of ribosome biogenesis. As shown by the increasing number of participants in the respective meetings, approximately 3,000 scientists are working on structural, functional, and biomedical aspects of ribosome biogenesis.