Brian Eyden
S. Sankar Banerjee
Yongxin Ru
Pawel Liberski
2013
Electron microscopy is one of the great techniques developed in the twentieth century with applications in the biological sciences, and it has played its part in revolutionising the way we understand the structure and function of cells and tissues. Following its development in the 1930s, electron microscopy was applied to biological specimens, including human tissues modified by disease, initially for the purposes of research. In the 1960s, however, it became clear that electron microscopy could also have diagnostic value in medicine, since it was found that particular diseases had characteristic ultrastructural features.