Michael R. Shurin • Viktor Umansky
Anatoli Malyguine
Editors
2013
The recent decade brought a tectonic shift in our understanding of the mechanisms regulating tumor development, progression, and metastases. During the majority of the last century, it was widely believed that these processes are governed mainly by genetic alterations in tumor cells. An incredible effort was expended to uncover the molecular mechanisms responsible for genomic instability, tumor cell survival, invasion, metastases, etc. Many transcription factors and signal transduction pathways were implicated in these processes.