Vassilios Vassiliou • Edward Chow
Dimitrios Kardamakis
Editors

2014

The impact of cancer on the skeleton can be devastating and typically results in a major decline in quality of life as well as reduced survival. Over the last decade or more, we have learnt a great deal about the cellular interactions that lead to the colonisation of bone by tumour cells and subsequent formation of metastases. This improved knowledge has helped the development of a range of bone-targeted treatments that have profoundly affected the clinical course of metastatic bone disease across the range of primary tumours that can affect the skeleton.