Editors 2013 Since the first introduction of CT Colonography, the technique and the clinical applications have matured in a very impressive manner. A large number of studies have shown that both sensitivity and speci fi city of the method are comparable with optical colonoscopy. Radiation exposure is definitely a major issue when using computed tomography for screening; however, by means of sophisticated CT technology including online dose modulation and iterative reconstruction of image data, CT Colonograpy has become a true “ultra low dose” application.