Edited by
Jacqueline M. Matthews

2012

Proteins do not act in isolation. They interact with lipids, nucleic acids, carbohydrates, small molecules and ions. And of course they interact with proteins—either like proteins (self-association/homo-oligomerization) or different proteins (heterologous association/ hetero-oligomerization). Protein-protein interactions lie at the heart of essentially all biological processes and large-scale efforts to map and characterize protein-protein interaction networks have formed a major research focus in the post-genomic era.