Margareta Hammarlund-Udenaes
Elizabeth C.M. de Lange • Robert G. Thorne
Editors

2014

Physiological Concepts, Methodologies
and Approaches

More than four decades have passed since Reese, Karnovsky, and Brightman used electron microscopy to unequivocally establish that tight junctions between brain endothelial cells form the blood–brain barrier (Brightman and Reese 1969; Reese and Karnovsky 1967). This finding ushered in a new era of research and science investigating precisely what factors determine transport across the blood–brain barrier (BBB), as well as the blood–cerebrospinal fluid barriers (BCSFB) formed by tight junctions between cells of the choroid plexus and arachnoid epithelia.