Akhlaq A. Farooqui
Wei-Yi Ong
Lloyd A. Horrocks

2008

About 40% of central nervous system synapses use glutamate as the neurotransmitter. It acts through ionotropic (NMDA, AMPA, and KA) and metabotropic types of glutamate receptors and plays crucial roles in developmental synaptogenesis, plasticity, long-term potentiation, and learning memory. Our understanding of the diversity, structure, and functions of various glutamate receptors has advanced significantly.