Michael E. Maragoudakis • Nikos E. Tsopanoglou
Physiology and Disease
The elucidation of the coagulation cascade has been one of the major accomplishments of biomedical sciences in recent years. The central role of thrombin, the plethora of factors and the multiple control mechanisms involved in haemostasis have been well characterized. However, new insights in the structure, functions and regulatory roles of thrombin in vascular physiology and development, in neuronal system, in tumor biology, tissue repair and angiogenesis have been gained by new powerful techniques and pioneering work of leading scientists.