Jawahar L. Mehta • Naranjan S. Dhalla
Editors
2013
Angiogenesis plays a key role in human physiology. For example, in utero angiogenesis is the backbone of vascular development as is hematopoiesis. Angiogenesis is a critical feature of wound healing and growth of uterine intima during the menstrual cycle. It has also become evident that angiogenesis is relevant in the genesis of diabetic retinopathy and growth of several tumors. Absent or suboptimal angiogenesis may relate to the syndrome of myocardial ischemia. In the last several years, a number of investigators have described various signals and pathways leading to the evolution and persistence of angiogenesis. These include a number of growth factors, receptors, redox state, and pro-in fl ammatory state.