Daniela Galimberti • Elio Scarpini
Editors

2014

Clinical Aspects, Molecular Genetics
and Biomarkers
More than a century ago, Alois Alzheimer and Gaetano Perusini described the intriguing case of a 51-year-old severely demented woman. They argued that specific changes in the brain (senile plaques and neurofibrillary tangles) were responsible for neuronal loss and dementia.