Swati Palit Deb • Sumitra Deb
Editors

2014

Since its discovery, p53 research has been the highlight of understanding the crucial role of oncogenes and tumor suppressors in regulated or deregulated cell growth. In the last decade, special attention was focused on gain of function mutations of p53 that can turn the tumor suppressor to an oncoprotein, as well as on abnormal expression of oncogenes such as MDM2 and MDMX that could inactivate the tumor suppressor function of p53 in the hope of devising cancer treatment