Jagdish N. Sharma
Editor

2014

Kinins are pharmacologically active polypeptides, which are formed in the tissues and body fluids as a result of the enzymatic action of kallikreins of kininogens. The kinin family includes bradykinin (BK) (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe- Arg), kallidin (Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg), and methiony-lysyl- BK (Met-Lys-Ard-Pro-Pro-Gly-Phe-Arg). Kallidin and methionyl-lysyl-BK are converted into BK by circulation aminopeptidases in plasma and urine. BK is rapidly inactivated by circulating kininases (Kininase I and Kininase II, known as angiotensin converting enzyme (ACE)).