Homocysteine in Protein Structure Function and Human Disease – Chemical Biology of Homocysteine-containing Proteins
Hieronim Jakubowski
2013
Proteins, the major functional macromolecules of life, are composed of long chains of L-α- mino acids linked by amide bonds between the α-caboxyl group of one residue and the α-amino group of the next. Although proteins contain several dozens to thousands of amino acid residues, only the 20 canonical coded amino acids, including two that contain sulfur—cysteine and methionine—are involved. Many diseases originate from mutations or modifications in proteins that affect their structure and cause a loss of function…