Jonathan R Seckl • Yves Christen
Editors

2014

In the last two decades a plethora of studies have extended the classical genes
 adult environment paradigm of disease aetiology to include early life development (genes
development
environment). An early and powerful example comes from the epidemiological studies of Barker and colleagues linking low birth weight (a rather blunt marker of “something went wrong in utero”) with a substantially increased risk of cardio-metabolic and neuropsychiatric disorders in later life.