Jacob P. Thyssen
Howard I. Maibach
Editors

2014

Basic Science, Epidemiology,
Clinical Aspects and Management

Filaggrin. Why a book on filaggrin?
As described below, there are indeed many good reasons to be interested in this particular molecule and its effects on human homeostasis. In 1977, Beverly Dale identified a “stratum corneum basic protein” (SCBP) that was rich in histidine and worked as an interfilamentous matrix substance. The term “filaggrin” (filament aggregating protein) was later coined when the investigators showed that the SCBP condensed and aligned keratin intermediate filaments in vitro.