Belma Turan • Naranjan S. Dhalla
Editors

2014

Biochemical and Molecular Mechanisms

Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search for the exact reason for its development. In the middle of the nineteenth century, autopsies of patients with diabetes mellitus showed damaged pancreases. The first evidence for the link between diabetes and the pancreas was provided in 1889 by O. Minkowski and J.V. Mering, who depancreatized a dog and demonstrated the development of polyuria, which was undistinguishable from diabetes.