Luca Saba • Jo˜ao Miguel Sanches
Lu´ıs Mendes Pedro • Jasjit S. Suri
Editors

2014

Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. However, until now, the exact plaque development/rupture mechanism has not been fully understood, and also the plaque rupture risk stratification. From biomechanical viewpoint, plaque initiation and development could be attributed to the disturbed flow in those arteries, and the sudden rupture of plaque can be resulted from plaque structure stability failure due to the mechanical stress in/outside plaque structure. Understanding this phenomenonwhy and how plaque develops and ruptures requires a multidisciplinary approach such as radiology, biomedical engineering, medical physics, software engineering, hardware engineering, and pathological and histological imaging.