Philip Rubin • Louis S. Constine
Lawrence B. Marks
Editors

2014

Volume 1: General Concepts and Specific
Precepts

In 1968, Casarett and Rubin proposed a paradigm to formally link acute and late effects as a biophysiopathologic and clinical continuum. Over the past four decades, numerous laboratory and clinical studies have provided additional insights to refine this paradigm. The first section of this book reviews the general concepts that frame the initial paradigm, and a series of paradigm shifts. These introductory chapters provide the foundation to the Organ/Site-specific chapters that form the core of this book.