Matjaž Vogelsang
Editor
2013
In 1913 Aldred Scott Warthin, a pathologist at the University of Michigan, described a family with distinct susceptibility to colon, gastric and uterine cancers, and referred to it as “cancer fraternity”. Today, one hundred years later, this same cancer family syndrome which is associated with greatly increased risks for developing colorectal cancer and endometrial cancer, is recognized as Lynch syndrome (LS), acknowledging the role of Henry T. Lynch who described the cardinal features of this predisposition. Our understanding and molecular diagnosis of LS has rapidly improved in the early 1990s, following the elucidation of the molecular mechanisms which cause the syndrome. Colorectal cancer is currently the fourth most frequent malignant disease.
DNA Alterations in Lynch Syndrome – Advances in molecular diagnosis and genetic counselling
