Complement Therapeutics
John D. Lambris • V. Michael Holers • Daniel Ricklin Editors
2013
The past decade has witnessed a new surge in the development of complement-targeted therapeutics, fueled by the successful launch of the fi rst complement pathway-specific inhibitors and the discovery of both orphan and highly prevalent diseases with contributions from complement. Apart from offering new hope for patients suffering from such diseases, the study of complement pathways, mutations, and de fi ciencies also teaches us important lessons about the role of complement in health and disease as well as allows us to re fi ne our models and tools for applied and basic research…