Larry K. Golightly • Isaac Teitelbaum
Tyree H. Kiser • Dimitriy A. Levin
Gerard R. Barber • Michael A. Jones
Nancy M. Stolpman • Katherine S. Lundin
Editors

2013

Dosage Adjustment of Medications
Eliminated by the Kidneys

For optimal effectiveness and safety, medications used to manage both acute and chronic diseases must be administered in dosages carefully tailored according to patient-specific metabolic and excretory functional capacity. Due to variably compromised ability to eliminate certain drugs from the body, patients with kidney disease often present with complex and potentially challenging clinical issues related to adjustment of drug dosages. In these patients, provision of effective and safe pharmacotherapy depends upon not only understanding the pharmacokinetic and pharmacodynamic actions of all prescribed medications but also comprehensive appreciation of each patient’s current clinical status.