Graham Hughes
Munther A. Khamashta

2013

In the 30 years since the description of the antiphospholipid syndrome (APS/Hughes syndrome), many clinical features have been added, emphasising the truly multisystem nature of the condition. Hughes syndrome is a challenge for clinicians for one reason in particular – its predilection to cross specialty borders. And because laboratory investigation of the syndrome is still far from perfect, the need for painstaking clinical observation is critical.