Cardiac Remodeling – Molecular Mechanisms
Bodh I. Jugdutt • Naranjan S. Dhalla Editors
2013
The concept of cardiac remodeling as a mechanism of heart disease leading to heart failure has evolved since the mid-1970s. The initial emphasis was on heart failure related to pressure and volume overload; this led to theories on adaptive and maladaptive structural and functional changes after life-threatening insults such as myocardial infarction and hypertensive heart disease. Later, the scope of cardiac remodeling expanded to pure and mixed pressure and volume overload states and a wide range of cardiomyopathies, inherited or acquired from infections or exposure to various therapeutic drugs with cardiotoxic pleiotropic effects and other cardiotoxic agents.