Editors: Resat Ozaras , Joop E. Arends

2019

Although a jaundice-like clinical disease patron was known already for centuries after its early descriptions by Hippocrates (Trepo et al. Liver Int. 2014 Feb;34 Suppl 1:29–37), its causative agents remained quite a mystery. The infectious origin was recognized through its epidemic form as opposed to the more recent serum origin, which was described by Lührman in 1885 who reported patients developing hepatitis after smallpox vaccination.