Editor Teresa Carlomagno

2009

Synthetic, Structural and Mechanistic
Insights

The multifaceted conformational properties of tubulin have represented a challenge for mechanistic and structural studies of the protein for the past 20 years. The conformational equilibrium between the dimeric and polymeric form of tubulin can be controlled by different solvents (H2O, D2O, DMSO), cofactors (divalent ions, as for example Mg2+, GTP/GDP), or small molecules.