Krishna R. Dronamraju ● Clair A. Francomano
Editors

2012

Hamilton O. Smith received an A.B. degree in mathematics at the University of California, Berkeley in 1952 and the M.D. degree from Johns Hopkins University in 1956. After 6 years of clinical work in medicine (1956–1962), he carried out research on Salmonella phage P22 lysogeny at the University of Michigan, Ann Arbor (1962–1967). In 1967, he joined the Microbiology Department at Johns Hopkins. In 1968, he discovered the first TypeII restriction enzyme (HindII) and determined the sequence of its cleavage site.