Fedor Berditchevski • Eric Rubinstein
Editors
2013
Since arriving at the molecular scene more than 20 years ago tetraspanins continue to capture imagination of researchers in various fi elds of biology. Initially described as targets for tumour-speci fi c mAbs (CO-029/TSPAN8, ME491/CD63), the antiproliferative mAb (TAPA-1/CD81/TSPAN28), and the antibodies recognising “cluster differentiation” (CD) antigens (CD9/TSPAN29, CD37/TSPAN26 and CD53/TSPAN25), tetraspanins later came into prominence as regulators of membrane dynamics which play an important role in cell-cell fusion, cell adhesion and endocytic traf fi cking.