Edited by
JAMES R. LUPSKI
PAWEL STANKIEWICZ

2006

For five decades since Fred Sanger’s seminal discovery that proteins have a specific structure, since Linus Pauling’s discovery that hemoglobin from patients with sickle cell anemia is molecularly distinct, and since Watson and Crick’s elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations affect the structure, function, or regulation of a gene or its protein product. Molecular medicine has functioned in the context of a genocentric world.