M. A. Khamashta (Ed.)

2006

Antiphospholipid Syndrome

The studies and discussions presented in the second edition of the Hughes Syndrome text had their beginning with a 1983 British Medical Journal publication entitled “Thrombosis, abortion, cerebral disease and the lupus anticoagulant.” In the mid-20th-century, it was recognized that some patients with systemic lupus erythematosus had biological false positive serological tests for syphilis, often coincident with the presence of an anticoagulant in plasma and the some of these patients (particularly ones with somewhat atypical of patterns of lupus) paradoxically manifested an increased incidence of procoagulant complications.