Edited by
SUDHIR GUPTA
FREDERICK ALT
MAX COOPER
FRITZ MELCHERS
KLAUS RAJEWSKY

2007

B Cell Biology

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated.