Edited by
MICHAEL A. CALIGIURI
MICHAEL T. LOTZE

2007

Cancer initiation and progression reflect the combined effects of tumor cellautonomous genetic alterations and the complex interplay of tumor cells with nontransformed host elements. Whereas intense effort has been directed towards elucidating the mechanisms by which mutations in oncogenes and tumor suppressors give rise to the hallmarks of cancer, increasing attention is being devoted to clarifying the role of host reactions in tumor pathogenesis.