O. Conneely, C. Otto
Editors

2008

From Basic Science to Clinical Applications

Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.