G. Kroemer, D. Mumberg, H. Keun, B. Riefke,
T. Steger-Hartmann, K. Petersen
Editors

2008

There is strong evidence for a common metabolic phenotype associated with cancer, observed both in vivo and in vitro, across species, and across a wide range of primary and secondary tumour sites. Already in 1920s, Otto Warburg described the phenomenon of “aerobic glycolysis”, the apparently greater tendency of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions.