Felix Bronner and Mary C. Farach-Carson (Eds.)

2009

Skeletal cancers may originate in bone as primary tumors, or arrive there as a consequence of the metastatic dissemination of cancer cells from distant sites, giving rise to secondary or tertiary tumors. Progression of malignant cancers in bone is fostered by the multipotential bone marrow stromal cells and the complex cellular milieu to which they give rise, including osteoblasts, osteoclasts, hematopoietic stem cells, bone marrow endothelial cells, and their precursors.