Edited by
Zahid H. Siddik

2009

Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss can occur through aberration in any one single component of the many signal transduction pathways that orchestrate checkpoint regulation, and results in either a failure to activate the checkpoint or a failure to respond to the activated checkpoint.