Marc Thiriet
2013
Modeling relies on access to data accumulated on any target object (configuration, structure, controlled functioning, fate under various types of stimuli, reaction to stresses that can be experienced, etc.). Knowledge is associated with a set of conditions: truth, belief justification, reliability, and stability. Understanding does not necessarily bring certitude before validation, especially in the absence of observation data. Volumes 1 to 4 of this series present events and their molecular participants that govern cell fate — intra-, auto-, juxta-, and paracrine — as well as possible endocrine regulations upon diverse types of stimuli, in the context of modeling and simulations.