Isabelle Couillin l Virginie Pe´trilli l
Fabio Martinon
Editors

2011

Innate immunity has been viewed as the first line of defense discriminating “self” (host proteins) from “non-self” (microorganisms). However, emerging literature suggests that innate immunity actually serves as a sophisticated system for sensing signals of “danger” such as pathogenic microbes or host-derived signals of cellular stress, while remaining unresponsive to non-dangerous motifs, such as normal host molecules.