Wyatt Travis Clark 2014 The development of effective methods for the prediction of ontological annotations is an important goal in computational biology, with protein function prediction and disease gene prioritization gaining wide recognition. While various algorithms have been proposed for these tasks, evaluating their performance is difficult due to problems caused both by the structure […]
Continue reading →
Bernard Puech • Jean-Jacques De Laey Graham E. Holder Editors 2014 A Textbook and Atlas Ophthalmogenetics and especially hereditary fundus disorders have become increasingly important not only for ophthalmologists and geneticists but also for other specialities such as dermatology, neurology, internal medicine, and otorhinolaryngology, and especially for the patients and their families.
Continue reading →
Daniela Galimberti • Elio Scarpini Editors 2014 Clinical Aspects, Molecular Genetics and Biomarkers More than a century ago, Alois Alzheimer and Gaetano Perusini described the intriguing case of a 51-year-old severely demented woman. They argued that specific changes in the brain (senile plaques and neurofibrillary tangles) were responsible for neuronal loss and dementia.
Continue reading →
Hans J. ten Donkelaar • Martin Lammens Akira Hori 2014 Development and Developmental Disorders of the Human Central Nervous System Apart from a general updating of the extensive literature on developmental neurobiology, neurogenetics, imaging and developmental neuropathology between 2005 and 2013, more emphasis has been given to: (a) imaging of the embryonic brain (early prenatal […]
Continue reading →
Federico E. Micheli • Peter A. LeWitt Editors 2014 Causes and Management Within the broad categories of neurologic diseases, the abnormal movement chorea (from Greek, choros , and from the Latin, choreus , both meaning dance) belongs among the conditions referred to as movement disorders. The field of movement disorders consists of both hypokinetic and […]
Continue reading →
Deborah Finkel · Chandra A. Reynolds Editors 2014 Advances in Behavior Genetics 1 Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception (Plomin et al. 2012). Darwin (1871) discussed commonalities between the mental powers of humans and other animals, implying a genetic […]
Continue reading →
Rudolf Happle 2014 Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia During my training in dermatology in the years 1968 through 1972, I had seen some linear skin lesions but never heard or read of Alfred Blaschko since, among dermatologists, his lines had fallen into oblivion. Shortly thereafter, when I worked at the University of […]
Continue reading →
Enid Gilbert-Barness • Diane E. Spicer Thora S. Steffensen 2014 The first edition of this text was published in 2005, and at that time was written with the explicit aim to fill a void in pediatric autopsy pathology. The autopsy still remains of paramount importance for accurate diagnoses, genetic counseling, and for the definitive diagnosis […]
Continue reading →
Debmalya Barh Editor 2014 Towards Next-Generation Diagnosis, Prognosis and Therapy Breast cancer is the leading cause of cancer specific deaths in women worldwide. Screening and early diagnosis provides better patient management, improves treatment efficacy, and reduce mortality. With the advent of nextgeneration “omics” technologies; several early markers, novel targets, and personalized targeted therapeutics are now […]
Continue reading →
He-Feng Huang • Jian-Zhong Sheng Editors 2014 Prenatal and early postnatal events increase the risk of some diseases in later life including diabetes, coronary heart disease and hypertension etc. In 1934, a landmark paper, published in the Lancet , found that death rates from all causes in the UK and Sweden decreased with each successive […]
Continue reading →