Category: Immunology

Biomaterials Associated Infection -Immunological Aspects and Antimicrobial Strategies

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Biomaterials Associated Infection-1

T. Fintan Moriarty • Sebastian A.J. Zaat Henk J. Busscher Editors 2013 The use of biomaterials in modern medicine has greatly contributed to patient care allowing less-invasive patient monitoring, improvements in the administration of medicines, and enhanced patient mobility contributing to improvements in quality of life. Relatively early in the evolution of medical devices, however, it was realized that […]

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Advances in HIV-1 Assembly and Release

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Advances in HIV-1 Assembly and Release-1

Eric O. Freed Editor 2013 The past decade has witnessed a tremendous advance in our understanding of HIV-1 replication at the molecular level. Rapid progress in this fi eld has been made possible by important developments in several key scientifi c disciplines. Superresolution microscopy has greatly increased our ability to pinpoint the localization of proteins in cells and on […]

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Tumor Ablation

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Tumor Ablation-1

Yona Keisari Editor 2013 Volume 5 Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions In recent years more data emerged on the role of intratumoral immune components and of other functions of the tumor microenvironment in the development or destruction of tumors. Tumor immunology and anti-tumor immunity started with the discovery that microbial agents can […]

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The Tumor Immunoenvironment

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The Tumor Immunoenvironment-1

Michael R. Shurin • Viktor Umansky Anatoli Malyguine Editors 2013 The recent decade brought a tectonic shift in our understanding of the mechanisms regulating tumor development, progression, and metastases. During the majority of the last century, it was widely believed that these processes are governed mainly by genetic alterations in tumor cells. An incredible effort was expended to […]

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Sphingolipids in Disease

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Sphingolipids in Disease-1

Erich Gulbins • Irina Petrache Editors 2013 Handbook of Experimental Pharmacology Volume 216 Until the late 1980s, sphingolipids were believed to represent structural components of the plasma membrane, whose function was to provide a protective barrier to the cell. This picture dramatically changed within the last years. Sphingolipids are now recognized signals for fundamental cellular processes such as […]

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Genomics of Pattern Recognition Receptors – Applications in Oncology and Cardiovascular Diseases

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Genomics of Pattern Recognition Receptors-1

Anton G. Kutikhin • Arseniy E. Yuzhalin 2013 The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. First, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called […]

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Human Immunodeficiency Virus Reverse Transcriptase – A Bench-to-Bedside Success

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Human Immunodeficiency Virus Reverse Transcriptase-1

Stuart LeGrice • Matthias Gotte Editors 2013 The Reverse Transcriptase (RT) of Human Immunodefi ciency Virus Type 1 (HIV-1) arguably ranks among one of the most extensively studied retroviral enzymes. Heterologous expression and purifi cation of HIV-1 RT in the early 1980s, approval of the fi rst nucleoside analogue RT inhibitor (NRTI) in 1987, discovery […]

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