Sandra L. Kane-Gill • Joseph Dasta (Editors) 2011 Critically ill patients are at risk for a higher frequency and severity of adverse drug events (ADEs) compared to non-critically ill patients. A contributing factor to this risk is the use of high-risk medications in the treatment of critically ill patients, often in combination. High-risk medications as […]
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Maria Sibilia l Christoph C. Zielinski l Rupert Bartsch l Thomas W. Grunt Editors 2011 Research over the last 2–3 decades in the fields of cell and molecular biology as ell as biomedicine has tremendously improved our understanding of the mechanisms of malignant transformation and progression. A lot of knowledge gained from these findings could already be […]
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Martin F. Fromm l Richard B. Kim Editors 2011 In the past 15 years, there has been a dramatic increase in the extent of our knowledge regarding the importance of transporter proteins that govern drug disposition and response. For example, the human multidrug and toxin extrusion protein 1, which is important for the elimination of organic cations and […]
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Stephen C. Piscitelli • Keith A. Rodvold Manjunath P. Pai Editors 2011 Drug-drug interactions are an under recognized source of medical errors that have major health related costs and consequences. Overriding drug interactions as ‘inconsequential’ is likely contributing to a silent epidemic. The association of sudden deaths as a consequence of antimicrobial drug-drug interactions speaks to this epidemic.
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Mathias Schwanstecher Editor 2011 Weight loss – in many cases, as little as 4 kg – with its pleiotropic benefits and optimal safety profile appears as the most effective means of managing type 2 diabetes (T2DM) (Harris 1991; Pories et al. 1995; Sjostrom et al. 2004; Pontiroli et al. 2005; Ratner et al. 2005; Pi-Sunyer et al. 2007; […]
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Bali Pulendran • Peter D. Katsikis Stephen P. Schoenberger Editors 2011 This volume presents a collection of reviews derived from work presented at the Aegean Conference, “3rd Crossroads between Innate and Adaptive Immunity,” which occured from September 27 to October 2, 2009 at the Minoa Palace Conference Center in Chania, Crete, Greece.
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Rüdiger Müller • Johannes von Kempis 2011 The simple goal of this book is to provide a comprehensive overview of clinical trials in rheumatology in an easily readable manner. The constantly growing and increasingly confusing multitude of clinical trials in inflammatory rheumatic diseases first gave us the idea.
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Jo C. Neill l Jayashri Kulkarni Editors 2011 This volume attempts to answer the question of how sex influences brain and behaviour. It brings together experts in this field, psychiatrists and other mental health care professionals with preclinical researchers to review the latest work in this area and give a thorough overview of how males and females are […]
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Yuriy A. Knirel l Miguel A. Valvano Editors 2011 Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells The lipopolysaccharide (LPS) is the major component of the outer leaflet of the outer membrane of Gram-negative bacteria. It contributes essentially to the integrity and stability of the outer membrane, represents an effective permeability barrier towards external stress factors, and […]
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Franz-Xaver Reichl • Michael Schwenk Editors 2014 Regulatory toxicology requires knowledge of aspects related to a number of disciplines of natural and social sciences, including chemistry, biology, bioinformatics, toxicology, epidemiology, exposure assessment and nutrition, as well as sociology, psychology and communication, to name a few. It builds a bridge between science and decision-making.
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