Glioma Cell Biology

Glioma Cell Biology-1

Aleksi Sedo • Rolf Mentlein Editors 2014 Gliomas are fatal malignant diseases, but also represent excellent models for tumor research with the aim to eventually discover new and appropriate therapeutics against this and other types of cancer. Gliomas are characterized by unregulated growth, apoptosis-resistance, diffuse invasion, strongly increased angiogenesis, and immunosuppression—all hallmarks of other tumor […]

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Cytopathology in Oncology

Cytopathology in Oncology-1

Ritu Nayar Editor 2014 Cytopathology, a branch of pathology that studies and diagnoses diseases at the cellular level, was founded by Rudolf Virchow in 1858. The first cytopathology test, the Pap (anicolaou) test for screening and diagnosis of cervical cancer, was developed over 50 years ago and has proven to be not only the most […]

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Trichloroethylene: Toxicity and Health Risks


Kathleen M. Gilbert • Sarah J. Blossom Editors 2014 This book is designed to highlight the best-characterized aspects of trichloroethylene (TCE) toxicity. These include both cancer and non-cancer endpoints. Epidemiologic data concerning the effects of TCE on human health are presented, as well as results obtained in animal models. When available, mechanistic information was provided, and future research directions […]

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Posttranslational Protein Modifications in the Reproductive System

Posttranslational Protein Modifications in the Reproductive System-1

Peter Sutovsky Editor 2014 By various accounts, the human genome includes up to 25,000 genes transcribed into messages from which a staggering one million of proteins and protein variants are derived that constitute the human body proteome. While some of this increase between gene and protein is due to alternative transcription and posttranscriptional processing of mRNA by alternative splicing, […]

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Molecular Mechanisms and Physiology of Disease

Molecular mechanisms and physiology of disease-1

Nilanjana Maulik • Tom Karagiannis Editors 2014 Implications for Epigenetics and Health Although coined in the 1940s by Conrad Waddington and now representing an intense field of biomedical research, the precise definition of Epigenetics remains controversial. In its simplest form epigenetics refers to heritable changes that are not due to changes in the underlying DNA sequence. Whereas DNA […]

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Interdisciplinary Concepts in Cardiovascular Health Volume III: Cardiovascular Events

Interdisciplinary Concepts in Cardiovascular Health-1

Ichiro Wakabayashi • Klaus Groschner Editors 2014 Volume III: Cardiovascular Events According to the recent WHO statistics, cardiovascular diseases are the leading cause of death globally with an estimated 17.3 million people dying from cardiovasculardisease in 2008, representing 30 % of all global deaths. Of these deaths, an estimated 7.3 and 6.2 million were attributed to coronary […]

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Impact of Sleep and Sleep Disturbances on Obesity and Cancer

Impact of Sleep and Sleep Disturbances on Obesity and Cancer-1

Susan Redline • Nathan A. Berger Editors 2014 Sleep has recently been recognized as a critical determinant of energy balance, regulating restoration and repair of many of the physiological and psychological processes involved in modulating energy intake and utilization. Emerging data indicate that sleep can now be added to caloric intake and physical activity as major determinants of energy […]

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Yi Ge • Songjun Li • Shenqi Wang Richard Moore Editors 2014 Principles of Nanomedicine Volume 1 This book is comprised of two complementary volumes: Principles of Nanomedicine (Volume 1) and Perspectives of Nanomedicine (Volume 2). The purpose of this arrangement is to provide a more comprehensive overview of a new and potentially revolutionary branch of healthcare – […]

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Molecular Mechanisms in Legionella Pathogenesis

Molecular Mechanisms in Legionella Pathogenesis-1

Hubert Hilbi Editor 2013 Legionnaires’ disease is a potentially fatal pneumonia primarily affecting elderly and immunocompromised persons. The disease is caused by the ubiquitous environmental bacterium Legionella pneumophila, which was first identified more than 35 years ago in the aftermath of a pneumonia epidemic that swept through a convent of the American Legion in Philadelphia, USA. The water-borne bacteria are […]

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