John H. Sinard 2006 Demystifying informatics for the practicing anatomic pathologist Almost all areas of intellectual pursuit in which there is an element of subjectivity share an interesting internal paradox. At first exposure, the field is a complete mystery. Then, as one acquires some of the domain knowledge and learns about the rules, the field starts to make sense, […]

Jesus M. Paramio 2006 Molecular biologists’ concept of cells is a “biological container” where important molecules float and interact with one another more or less randomly. However, a close view of this “bag” reveals an astonishing net of fibrous proteins crossing throughout the cytoplasm: the cytoskeleton.  

Edited by JAMES R. LUPSKI PAWEL STANKIEWICZ 2006 For five decades since Fred Sanger’s seminal discovery that proteins have a specific structure, since Linus Pauling’s discovery that hemoglobin from patients with sickle cell anemia is molecularly distinct, and since Watson and Crick’s elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in […]