Gerhard Klebe 2013 Methodology, Concepts, and Mode-of-Action The present handbook on drug design builds on the German version first written by Hans-Joachim Bo¨hm, Hugo Kubinyi, and me in 1996. After 12 years of success on the market, the German version of this handbook was entirely rewritten and significantly extended, then by me as the sole author. The new […]

Maria Spies Editor 2013 A plethora of molecular motors hustle and bustle along the chromosomes of all living cells. Distinct among them are helicases, classified by the presence of the socalled helicase signature motifs in their amino acid sequences. Helicases were discovered in the 1970s and were reputed to be the enzymes that “unwind” duplex nucleic acids in an […]

Alexey Melkikh • Maria Sutormina 2013

Elisabeth Hildt • Andreas G. Franke Editors 2013 An Interdisciplinary Perspective This book is a collection of contributions to the conference “Cognitive Enhancement,” which was held from 21 February until 1 March 2011 at the University of Mainz, Germany. During this interdisciplinary conference, young scholars from Europe, Canada and Australia met to present their work and to discuss […]

Kerry L. Tucker • Tamara Caspary Editors 2013

Edited by C. Van Cheng 2013 I learned about Sertoli cells and germ cells in the testis and the concept of the blood-testis barrier when I was a graduate student in the late 1970s in the laboratory of Professor Barry Boettcher, University of Newcastle, Australia. Thereafter, I joined the Laboratory of Dr. Wayne Bardin in the Population Council’s […]

Hrvoj Vancik 2013 It is almost impossible to explain how a scientist who is engaged in the basic science creates his field of research. This personal process cannot be comprised within any of the formal concepts of philosophy of science. It could just appear that, during the work, an extra observation discovers a new phenomenon so interesting and intriguing […]

Thomas Jue • Kazumi Masuda Editors 2013 The advent of near-infrared spectroscopy (NIRS) presents a unique tool for understanding the regulation of oxidative metabolism during the transition from rest to an active state. Many laboratories have started to apply NIRS to interrogate both cerebral and muscle metabolism and have garnered insights to discriminate the bioenergetics and hemodynamics of […]