C. Alexander Valencia • M. Ali Pervaiz Ammar Husami • Yaping Qian • Kejian Zhang 2013 The purpose of this book is to serve as an introduction to those that want to learn about next-generation–sequencing (NGS) and its applications. However, from the middle to end of each chapter a more in-depth approach will be taken to satisfy […]

Ali Masoudi-Nejad • Zahra Narimani Nazanin Hosseinkhan 2013 Methodologies and Algorithms DNA sequencing is a fast-moving science with technologies and platforms being updated at breathtaking speed. The hallmark of next generation sequencing (NGS) has been a massive increase in throughput and a decrease in price compared with previous technologies. The first next-generation DNA sequencing machine was introduced to the […]

Lee-Jun C. Wong Editor 2013 Translation to Clinical Diagnostics The recent development of high-throughput next-generation sequencing (NGS) technology has transformed the way DNA-based molecular diagnostic testing is performed in clinical laboratories. NGS allows parallel sequencing analyses of multiple genes effectively at any desirable depth of coverage.

Edited by Pierre Busson 2013 Keys for Translational Medicine and Biology Although listed as a rare cancer in a majority of countries, nasopharyngeal carcinoma (NPC) has a high incidence and appears as a serious public health problem in several highly populated areas of Southeast Asia and to a lesser extent in North Africa. Worldwide, its incidence rates at […]

Brian Henderson Editor 2013 It is now clearly recognised that infection of metazoans by microbial pathogens involves significant molecular and cellular interactions between host and pathogen. It is also recognised that microbial infection is a major cause of stress, both for the invading microbe and the invaded host.

Mauro D’Amato • John D. Rioux Editors 2013 If you are picking up this book for the very first time you might be asking yourself why it is entirely dedicated to the topic of the Molecular Genetics of IBD —or more specifically, why IBD and why now? The simplest answer is that research in Crohn’s disease (CD) and […]

Amit Singh • Madhuri Kango-Singh Editors 2013

Ahmad M. Khalil • Jeff Coller Editors 2013 The mammalian genome encodes both coding and non-coding transcripts that work synergistically to build and organize cellular structures, and regulate gene expression patterns, which ultimately determine cell identity and function. While coding transcripts serve mostly as templates for protein synthesis, non-coding RNA transcripts, which by definition lack significant protein-coding capacity, participate in […]

Gary Stephens • Sumiko Mochida Editors 2013 This book unites leading international experts to discuss recent advances in the regulation of mammalian presynaptic voltage-gated Ca2C channels (VGCCs). It is now commonly realised that VGCC expression is a hallmark characteristic of an excitable cell.