Kenneth A. Howard Editor 2013 The 2006 Nobel Prize in Medicine or Physiology was awarded to Andrew Fire and David Mello for their 1998 discovery of double-stranded RNA-mediated gene silencing by the process of RNA interference (RNAi). The capability to control and study cellular gene expression has opened up completely new research areas, shed exciting new light on existing […]

David A. Dougan Editor 2013 All cells are composed of thousands of different proteins, each with a specific function. Collectively these proteins contribute to the proper function and maintenance of cells. As such it is not surprising, that regulating the integrity and concentration of each protein in the cell, not only under normal conditions but also under conditions of […]

Dariusz Leszczynski Editor 2013 The effects of ionizing and non-ionizing radiation on cells and tissues Proteomics is widely used in search of biomarkers, in pharmacology, in clinical research and in toxicology. With the help of proteomics, large amount of information on the physiology of living cells can be obtained in a single experiment.

Jonathan Mamou • Michael L. Oelze Editors 2013 In the 1970s, Holasek, Gans, Purnell, and Sokollu expressed the notion that the frequency content of medical-ultrasound echo signals might be exploited to characterize soft tissue; they developed a method of color-encoding of B-scan images to depict spectral content of RF echo signals and termed the method ‘‘spectra color.’’ By characterize, […]

Daan J.A. Crommelin • Robert D. Sindelar Bernd Meibohm Editors 2013 Fundamentals and Applications Over the past 25 years, biotechnologically derived drug products have become a major share of the therapeutically used pharmaceuticals. These drug products include proteins, including monoclonal antibodies and antibody fragments, as well as antisense oligonucleotides and DNA preparations for gene therapy.

Luis A. del R´ıo Editor 2013 Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism.When these organelles were first isolated and characterized from mammalian tissues in the beginning of the 1960s by Christian de Duve, it was thought that their main function was the removal by […]

Debmalya Barh • Dipali Dhawan Nirmal Kumar Ganguly Editors 2013 The goal of humankind is to alleviate the human suffering through the gain of knowledge. In the last few decades, the rapid advancement of “omics” technologies has shown us a way to understand the genetic causes of diseases that has led the way for better treatment options and […]

Sanjay Patole Editor 2013 A Clinical Perspective Survival of extremely preterm neonates (gestation within 28 weeks from birth) has improved significantly following the advances in neonatal intensive care. Extra uterine growth restriction is a serious issue in this population. Nutritional exposures during this critical period in life influence the individual’s risk of disease throughout life.

Rodrigo J. Carbajo • José L. Neira 2013 This book in the Springer Brief Series intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the past 20 years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can […]