David A. Schwartz Editor 2011 The Making of Physician-Scientists I’ve always wondered what pushes or pulls people toward one career or another. Life choices make for life consequences, but what goes into these choices? The daily encounters, chance meetings, and derived opportunities, combined with the inherent individual values and attributes, allow one to weave through this complex maze of […]

Edited by Antonio Rodríguez-Moreno Talvinder S. Sihra 2011 Novel Signaling Insights This volume critically examines the functional actions of the kainate-type glutamate receptors (KARs). Following on from the larger body of work on the NMDA- and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an […]

Tamara Fischmann • Elisabeth Hildt Editors 2011 The book “Ethical dilemmas in prenatal diagnosis” is based on the contributions to the international conference “Ambivalence of the technological progress in medicine” which was held in September 2008 in Frankfurt/Main, Germany. The focus of this conference was on technological developments in the life sciences which – often tacitly – confront us […]

Edited by Esteban Ballestar 2011 During the past few years, attention towards epigenetics has experienced an unprecedented growth. Interestingly, despite that epigenetics has become a very popular term in molecular biology and biomedicine, its definition still is in evolution, perhaps because the boundaries of epigenetic regulation and epigenetic phenomena are still unkown.

Edited by Mark W. Robinson John P. Dalton 2011 Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This volume gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years.

Editors:  Hugh D.C. Smyth, Anthony J. Hickey 2011 The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung are surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary […]

Holly H. C. Kimko l Carl C. Peck Editors 2011 Applications and Trends During the seven years following the inaugural publication of Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective, acceptance and application of clinical trials modeling and simulation (M&S) in drug development and regulation have greatly expanded. Biopharmaceutical companies have employed M&S in all phases of drug […]

Gáspár Bánfalvi Editor 2011 Cellular lesions are related to macromolecular synthetic processes including the hierarchical flow of genetic information. Heavy metals generate oxidizing radicals through the Fenton and Haber-Weiss reactions leading to metal-induced carcinogenesis mediated primarily by the elevated levels of reactive oxygen species.

Yasushi Sako l Masahiro Ueda Editors 2011 Single-Molecular Kinetic Analysis The biological cell, the minimal unit of life, is an extremely complicated reaction web. The human genome project has revealed that 20,000–30,000 genes are encoded in single human cells; these genes are thought to produce more than 100,000 protein species through alternative splicing and chemical modification.

Lars-Inge Larsson Editor 2011 Regulation and Control The fusion between the sperm and the egg marks the beginning of life and a number of subsequent cell fusions are needed to form the placenta, the skeleton, the skeletal muscles and part of our immune defence system. Cell fusions are also needed during adulthood, e.g. to regulate our calcium homeostasis.